Cuprizone-induced demyelination in the rat cerebral cortex and thyroid hormone effects on cortical remyelination

@article{Silvestroff2012CuprizoneinducedDI,
  title={Cuprizone-induced demyelination in the rat cerebral cortex and thyroid hormone effects on cortical remyelination},
  author={Lucas Silvestroff and Sandra Bartucci and Juana Mar{\'i}a Pasquini and Paula Gabriela Franco},
  journal={Experimental Neurology},
  year={2012},
  volume={235},
  pages={357-367}
}
Cuprizone-induced demyelination in Wistar rats; electrophysiological and histological assessment.
TLDR
6 weeks of cuprizone feedings could be suitable to bring into existence of MS model in Wistar rats and demyelinated areas and vacuolization were seen on the brain sections of CPZ exposed rats.
Thyroid hormone alleviates demyelination induced by cuprizone through its role in remyelination during the remission period
TLDR
It was shown that TH alleviated demyelination induced by CPZ by promoting the development of oligodendrocyte lineage cells and remyelinations and reducing the number of astrocytes without affecting microglia.
Five Decades of Cuprizone, an Updated Model to Replicate Demyelinating Diseases
TLDR
The model of toxic demyelination induced by cuprizone (CPZ), a copper chelator that reduces the cytochrome and monoamine oxidase activity into the brain, produces mitochondrial stress and triggers the local immune response, is described.
Regulatory effect of triiodothyronine on brain myelination and astrogliosis after cuprizone-induced demyelination in mice
TLDR
It is shown that T3 promotes remyelination in chronic lesions by both enhancing oligodendrocyte maturation and attenuating astrogliosis, and intermediate filament proteins vimentin and nestin as well as the extracellular matrix component tenascin C were significantly reduced after T3 exposure, indicating additional effects of T3 on astrocytes and astrogLiosis.
Glial response during cuprizone-induced de- and remyelination in the CNS: lessons learned
TLDR
The cuprizone model is reviewed to demonstrate that there is an important crosstalk between astrocytes and microglia and its potential therapeutic relevance for the human disease MS are critically discussed in comparison to other animal models.
Anti-CD20 treatment effectively attenuates cortical pathology in a rat model of widespread cortical demyelination
TLDR
A marked reduction of cortical demyelination, microglial activation, astrocytic reaction, and apoptotic cell loss in anti-CD20 antibody treated groups is observed, indicating a favorable impact of anti- CD20 therapy.
Myelin repair stimulated by CNS-selective thyroid hormone action.
TLDR
It is shown that chronic treatment with sobetirome or Sob-AM2 leads to significant improvement in both clinical signs and remyelination, and these results support the clinical investigation of selective CNS-penetrating TH agonists, but not TH, for myelin repair.
Modelling Demyelination and Neuronal Loss from Diffusion Weighted Magnetic Resonance Images in an Experimental Model of Multiple Sclerosis
This master project is an application of an advanced biophysical model of water diffusion in tissue to asses neuronal microstructure of mouse and rat brain and, in particular, to find potential
Promotion of Remyelination by Sulfasalazine in a Transgenic Zebrafish Model of Demyelination
TLDR
The data suggest that temporal modulation of the immune response by sulfasalazine can be used to overcome MS by enhancing myelin repair and remyelination in the CNS.
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