Cuprizone-Induced Demyelination as a Tool to Study Remyelination and Axonal Protection

@article{Zendedel2013CuprizoneInducedDA,
  title={Cuprizone-Induced Demyelination as a Tool to Study Remyelination and Axonal Protection},
  author={Adib Zendedel and Cordian Beyer and Markus Kipp},
  journal={Journal of Molecular Neuroscience},
  year={2013},
  volume={51},
  pages={567-572}
}
In the brain of multiple sclerosis (MS) patients, the conduction block of axons due to demyelination and inflammation underlies early neurological symptoms, whereas axonal transection accounts for permanent deficits occurring during later disease stages. The beneficial function of myelin for the protection of the axonal compartment and network stability between neurons has been shown in numerous studies. Thus, rapid and adequate remyelination is an important factor for axonal patronage during… CONTINUE READING
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