Cup is a nucleocytoplasmic shuttling protein that interacts with the eukaryotic translation initiation factor 4E to modulate Drosophila ovary development.

@article{Zappavigna2004CupIA,
  title={Cup is a nucleocytoplasmic shuttling protein that interacts with the eukaryotic translation initiation factor 4E to modulate Drosophila ovary development.},
  author={Vincenzo Zappavigna and Federica Piccioni and Juan Carlos Villaescusa and Arturo C. Verrotti},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2004},
  volume={101 41},
  pages={14800-5}
}
In Drosophila, the product of the fs (2)cup gene (Cup) is known to be crucial for diverse aspects of female germ-line development. Its functions at the molecular level, however, have remained mainly unexplored. Cup was found to directly associate with eukaryotic translation initiation factor 4E (eIF4E). In this report, we show that Cup is a nucleocytoplasmic shuttling protein and that the interaction with eIF4E promotes retention of the Cup protein in the cytoplasm. Cup is required for the… CONTINUE READING

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