Cumulative risk impact of five genetic variants associated with papillary thyroid carcinoma.

@article{Liyanarachchi2013CumulativeRI,
  title={Cumulative risk impact of five genetic variants associated with papillary thyroid carcinoma.},
  author={Sandya Liyanarachchi and Anna W{\'o}jcicka and Wei Li and Malgorzata Czetwertyńska and Elżbieta Stachlewska and Rebecca S. Nagy and Kevin W. Hoag and Bernard Wen and Rafal Ploski and Matthew D. Ringel and Izabella Kozłowicz-Gudzińska and Wojciech Gierlikowski and Krystian Jażdżewski and Huiling He and Albert de la Chapelle},
  journal={Thyroid : official journal of the American Thyroid Association},
  year={2013},
  volume={23 12},
  pages={1532-40}
}
BACKGROUND Two recent genome-wide association studies (GWASs) identified five single nucleotide polymorphisms (SNPs; rs965513, rs944289, rs966423, rs2439302, and rs116909374) associated with papillary thyroid carcinoma (PTC). Each variant showed highly significant but moderate to low disease risk. Here we assessed the cumulative risk and predictive value of the five SNPs. METHODS We genotyped two cohorts of individuals, 747 PTC cases and 1047 controls from Ohio and 1795 PTC cases and 2090… CONTINUE READING