Cumulative number of altered biomarkers in mammalian target of rapamycin pathway is an independent predictor of outcome in patients with clear cell renal cell carcinoma.

@article{Darwish2013CumulativeNO,
  title={Cumulative number of altered biomarkers in mammalian target of rapamycin pathway is an independent predictor of outcome in patients with clear cell renal cell carcinoma.},
  author={Oussama M Darwish and Payal Kapur and Ramy F. Youssef and Aditya Bagrodia and Michael James Belsante and Feras Alhalabi and Arthur I. Sagalowsky and Yair Lotan and Vitaly Margulis},
  journal={Urology},
  year={2013},
  volume={81 3},
  pages={
          581-6
        }
}
OBJECTIVE To evaluate the association of the altered expression of the mammalian target of rapamycin (mTOR) pathway components with oncologic outcomes in patients with nonmetastatic clear cell renal cell carcinoma (ccRCC). MATERIALS AND METHODS Immunohistochemistry for phosphorylated-S6, phosphorylated-mTOR, mTOR, phosphorylated-AKT, hypoxia inducible factor-1α, Raptor, phosphatase and tensin homolog (PTEN), phosphoinositide 3-kinase (PI3K), and phosphorylated 4E-binding protein-1 was… CONTINUE READING
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