Cumulative mutations of ubiquitin acceptor sites in human immunodeficiency virus type 1 gag cause a late budding defect.

@article{Gottwein2006CumulativeMO,
  title={Cumulative mutations of ubiquitin acceptor sites in human immunodeficiency virus type 1 gag cause a late budding defect.},
  author={Eva Gottwein and Stefanie J{\"a}ger and Anja Habermann and Hans-Georg Kr{\"a}usslich},
  journal={Journal of virology},
  year={2006},
  volume={80 13},
  pages={6267-75}
}
The p6 domain of human immunodeficiency virus type 1 (HIV-1) Gag has long been known to be monoubiquitinated. We have previously shown that the MA, CA, and NC domains are also monoubiquitinated at low levels (E. Gottwein and H. G. Krausslich, J. Virol. 79:9134-9144, 2005). While several lines of evidence support a role for ubiquitin in virus release, the relevance of Gag ubiquitination is unclear. To directly address the function of Gag ubiquitination, we constructed Gag variants in which… CONTINUE READING
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