Cumulative estrogen exposure, number of menstrual cycles, and Alzheimer's risk in a cohort of British women.

@article{Fox2013CumulativeEE,
  title={Cumulative estrogen exposure, number of menstrual cycles, and Alzheimer's risk in a cohort of British women.},
  author={Molly Fox and Carlo Berzuini and Leslie A. Knapp},
  journal={Psychoneuroendocrinology},
  year={2013},
  volume={38 12},
  pages={2973-82}
}
The effect of estrogen on Alzheimer's Disease (AD) risk has received substantial research and media attention, especially in terms of hormone replacement therapy. But reproductive history is also an important modifier of estrogenic exposure, and deserves further investigation. Importantly, there is wide variation in reproductive patterns that modifies estrogen exposure during the reproductive span, which previous AD studies have not incorporated into their calculations. We measured degree of… CONTINUE READING
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