Cumulative effects of the ApoE genotype and gender on the synaptic proteome and oxidative stress in the mouse brain.

@article{Shi2014CumulativeEO,
  title={Cumulative effects of the ApoE genotype and gender on the synaptic proteome and oxidative stress in the mouse brain.},
  author={Lv Shi and Xin Du and Hong Zhou and Changlu Tao and Yuntao Liu and Fantao Meng and Gao Wu and Ying Xiong and Chun Xia and Yu Wang and Guoqiang Bi and Jiang-Ning Zhou},
  journal={The international journal of neuropsychopharmacology},
  year={2014},
  volume={17 11},
  pages={1863-79}
}
Elderly females, particularly those carrying the apolipoprotein E (ApoE)-ε4 allele, have a higher risk of developing Alzheimer's disease (AD). However, the underlying mechanism for this increased susceptibility remains unclear. In this study, we investigated the effects of the ApoE genotype and gender on the proteome of synaptosomes. We isolated synaptosomes and used label-free quantitative proteomics, to report, for the first time, that the synaptosomal proteomic profiles in the cortex of… CONTINUE READING
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