Cumulative and bolus in vitro contracture testing with 4-chloro-3-ethylphenol in malignant hyperthermia positive and negative human skeletal muscles.

@article{Gerbershagen2005CumulativeAB,
  title={Cumulative and bolus in vitro contracture testing with 4-chloro-3-ethylphenol in malignant hyperthermia positive and negative human skeletal muscles.},
  author={Mark Ulrich Gerbershagen and Marko Fiege and Ralf Weisshorn and Kerstin Kolodzie and Jochen Schulte am Esch and Frank Wappler},
  journal={Anesthesia and analgesia},
  year={2005},
  volume={101 3},
  pages={710-4, table of contents}
}
In this study we evaluated the in vitro effects of 4-chloro-3-ethylphenol (CEP) using cumulative (12.5-200 micromol/L) or bolus (75 and 100 micromol/L) administrations, on muscle specimens from malignant hyperthermia (MH) susceptible and MH nonsusceptible patients, respectively. In the cumulative CEP in vitro contracture test, contractures were significantly greater in the MH susceptible compared with the MH nonsusceptible muscles in all concentrations between 25 and 100 micromol/L. There was… CONTINUE READING