Cumulative activation of voltage-dependent KVS-1 potassium channels.

  title={Cumulative activation of voltage-dependent KVS-1 potassium channels.},
  author={Patricio Gajardo Rojas and Jonathan Garst-Orozco and Beravan Baban and Jose Antonio de Santiago-Castillo and Manuel Covarrubias and Lawrence Salkoff},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={28 3},
In this study, we reveal the existence of a novel use-dependent phenomenon in potassium channels, which we refer to as cumulative activation (CA). CA consists of an increase in current amplitude in response to repetitive depolarizing step pulses to the same potential. CA persists for up to 20 s and is similar to a phenomenon called "voltage-dependent facilitation" observed in some calcium channels. The KVS-1 K+ channel, which exhibits CA, is a rapidly activating and inactivating voltage… CONTINUE READING