Cumulative Impact of Polychlorinated Biphenyl and Large Chromosomal Duplications on DNA Methylation, Chromatin, and Expression of Autism Candidate Genes.

@article{Dunaway2016CumulativeIO,
  title={Cumulative Impact of Polychlorinated Biphenyl and Large Chromosomal Duplications on DNA Methylation, Chromatin, and Expression of Autism Candidate Genes.},
  author={Keith W Dunaway and Mohammad Saharul Islam and Rochelle L Coulson and Shirley L{\'o}pez and Annie Vogel Ciernia and Roy G Chu and Dag H Yasui and Isaac N Pessah and Paul Lott and Charles E Mordaunt and Makiko Meguro-Horike and Shin-Ichi Horike and Ian F Korf and Janine M LaSalle},
  journal={Cell reports},
  year={2016},
  volume={17 11},
  pages={3035-3048}
}
Rare variants enriched for functions in chromatin regulation and neuronal synapses have been linked to autism. How chromatin and DNA methylation interact with environmental exposures at synaptic genes in autism etiologies is currently unclear. Using whole-genome bisulfite sequencing in brain tissue and a neuronal cell culture model carrying a 15q11.2-q13.3 maternal duplication, we find that significant global DNA hypomethylation is enriched over autism candidate genes and affects gene… CONTINUE READING
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