Culturing on Wharton's Jelly Extract Delays Mesenchymal Stem Cell Senescence through p53 and p16INK4a/pRb Pathways

@inproceedings{Hao2013CulturingOW,
  title={Culturing on Wharton's Jelly Extract Delays Mesenchymal Stem Cell Senescence through p53 and p16INK4a/pRb Pathways},
  author={Haojie Hao and Guanghui Chen and Jiejie Liu and Dongdong Ti and Yali Zhao and Shenjun Xu and Xiaobing Fu and Weidong Han},
  booktitle={PloS one},
  year={2013}
}
Mesenchymal stem cells (MSCs) hold great therapeutic potential. However, MSCs undergo replication senescence during the in vitro expansion process. Wharton's jelly from the human umbilical cord harbors a large number of MSCs. In this study, we hypothesized that Wharton's jelly would be beneficial for in vitro expansion of MSCs. Wharton's jelly extract (WJEs), which is mainly composed of extracellular matrix and cytokines, was prepared as coating substrate. Human MSCs were isolated and cultured… CONTINUE READING

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