Cultured neurofibromatosis tumor fibroblasts lack beta-adrenergic receptors.

@article{Kaila1988CulturedNT,
  title={Cultured neurofibromatosis tumor fibroblasts lack beta-adrenergic receptors.},
  author={Timo J Kaila and Risto Penttinen and Juha M. Peltonen},
  journal={Neurofibromatosis},
  year={1988},
  volume={1 1},
  pages={37-42}
}
Beta-adrenergic receptors on cultured neurofibromatosis (NF) skin and tumor fibroblasts were characterized by a radioligand binding assay using (-)-125I-iodocyanopindolol (ICYP), a potent beta-antagonist. NF tumor fibroblasts had a very low density of beta-adrenergic receptors (0-450 binding sites/cell) when compared to fibroblasts obtained from a healthy skin area of NF patients or from healthy controls (average 1,800 binding sites/cell). The apparently low binding of ICYP to the NF tumor… CONTINUE READING