Cultured hepatocytes adopt progenitor characteristics and display bipotent capacity to repopulate the liver.

@article{Krause2014CulturedHA,
  title={Cultured hepatocytes adopt progenitor characteristics and display bipotent capacity to repopulate the liver.},
  author={P. -H. Krause and Kirsten Unthan-Fechner and Irmelin Probst and Sarah Koenig},
  journal={Cell transplantation},
  year={2014},
  volume={23 7},
  pages={805-17}
}
Clinical studies have proved the therapeutic potential of hepatocyte transplantation as a promising alternative to whole organ liver transplantation in the treatment of hereditary or end-stage liver disease. However, donor shortage seriously restricts cell availability, and the lack of appropriate cell culture protocols for the storage and maintenance of donor cells constitutes a significant obstacle. The aim of this study was to stimulate mature hepatocytes in culture to multiply in vitro and… CONTINUE READING
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