Cultured endometrial cancer cells exhibit autocrine growth factor stimulation that is not observed in cultured normal endometrial cells.

@article{Reynolds1996CulturedEC,
  title={Cultured endometrial cancer cells exhibit autocrine growth factor stimulation that is not observed in cultured normal endometrial cells.},
  author={R. Kevin Reynolds and Charles A. Owens and Jennifer A. Roberts},
  journal={Gynecologic oncology},
  year={1996},
  volume={60 3},
  pages={380-6}
}
OBJECTIVE To evaluate the autocrine stimulation hypothesis, primary cultures of malignant and normal endometrium were assayed for differences in response to growth factors (GF) GF and receptor blocking antibodies. METHODS Thirteen normal and 10 malignant endometrial samples were collected. Cells were enzymatically dispersed and maintained in serum-free medium. They were incubated with epidermal GF (EGF), transforming GF-alpha (TGF-alpha), insulin-like GF-I (IGF-1), anti-EGF receptor antibody… CONTINUE READING