Cultured adult rat jejunal explants as a model for studying regulation of CYP3A.

@article{SchmiedlinRen1993CulturedAR,
  title={Cultured adult rat jejunal explants as a model for studying regulation of CYP3A.},
  author={Phyllissa Schmiedlin-Ren and Patrick E. Benedict and William O. Iii Dobbins and Moumita Ghosh and Joseph C Kolars and Paul B Watkins},
  journal={Biochemical pharmacology},
  year={1993},
  volume={46 5},
  pages={
          905-18
        }
}
Enzymes within the CYP3A subfamily are major Phase I drug-metabolizing enzymes present in hepatocytes and small bowel enterocytes. These enzymes are highly inducible in the liver by many structurally diverse compounds, including a number of commonly used medications. Studies indicate that CYP3A enzymes present in small bowel enterocytes are also inducible. However, the regulation of CYP3A enzymes in this tissue has not been well characterized, in part because in vivo studies are difficult… CONTINUE READING

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