Cultured adherent cells from marrow can serve as long-lasting precursor cells for bone, cartilage, and lung in irradiated mice.

@article{Pereira1995CulturedAC,
  title={Cultured adherent cells from marrow can serve as long-lasting precursor cells for bone, cartilage, and lung in irradiated mice.},
  author={R. F. Pereira and Karen W. Halford and Mary-Clare O'Hara and Dennis B. Leeper and Boris P. Sokolov and Michelle Pollard and Omar Bagasra and D. J. Prockop},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1995},
  volume={92 11},
  pages={4857-61}
}
Cells from transgenic mice expressing a human mini-gene for collagen I were used as markers to follow the fate of mesenchymal precursor cells from marrow that were partially enriched by adherence to plastic, expanded in culture, and then injected into irradiated mice. Sensitive PCR assays for the marker collagen I gene indicated that few of the donor cells were present in the recipient mice after 1 week, but 1-5 months later, the donor cells accounted for 1.5-12% of the cells in bone, cartilage… CONTINUE READING