Cultured Skin Fibroblasts Isolated from Mice Devoid of the Prion Protein Gene Express Major Heat Shock Proteins in Response to Heat Stress

@article{Satoh1998CulturedSF,
  title={Cultured Skin Fibroblasts Isolated from Mice Devoid of the Prion Protein Gene Express Major Heat Shock Proteins in Response to Heat Stress},
  author={Jun-ichi Satoh and Motohiro Yukitake and Kazuhiro Kurohara and Noriyuki Nishida and Yasuo Kuroda},
  journal={Experimental Neurology},
  year={1998},
  volume={151},
  pages={105-115}
}
Recent evidence has suggested that molecular chaperones participate in the conformational change between the normal cellular prion protein (PrPC) and its scrapie isoform (PrPSc). To study a role of PrPC in the regulation of expression of heat shock proteins (HSPs), a group of molecular chaperones, heat-induced expression of major HSPs (HSP105, HSP90alpha, HSP72, HSC70, HSP60, and HSP25) was investigated in cultured skin fibroblasts isolated from the mice homogeneous for a disrupted PrP gene… CONTINUE READING
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