Cultured Hippocampal Pyramidal Neurons Express Two Kinds of GABAA Receptors.

  title={Cultured Hippocampal Pyramidal Neurons Express Two Kinds of GABAA Receptors.},
  author={Patrick S Mangan and Chengsan Sun and Mackenzie Carpenter and Howard P Goodkin and Werner Sieghart and Jaideep Kapur},
  journal={Molecular pharmacology},
  volume={67 3},
We combined a study of the subcellular distribution of the alpha1, alpha2, alpha4, beta1, beta2/3, gamma2, and delta subunits of the GABAA receptor with an electrophysiological analysis of GABAA receptor currents determine the to types of receptors expressed on cultured hippocampal pyramidal neurons. The immunocytochemistry study demonstrated that alpha1, alpha2, beta2/3, and gamma2 subunits formed distinct clusters of various sizes, which were colocalized with clusters of glutamate… CONTINUE READING


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