Culture systems for hepatitis E virus

  title={Culture systems for hepatitis E virus},
  author={Hiroaki Okamoto},
  booktitle={Journal of Gastroenterology},
The lack of an efficient cell culture system for hepatitis E virus (HEV) has greatly hampered detailed analyses of this virus. The first efficient cell culture systems for HEV that were developed were capable of secreting infectious HEV progenies in high titers into culture media, using PLC/PRF/5 cells derived from human hepatocellular carcinoma and A549 cells derived from human lung cancer as host cells. The success achieved with the original genotype 3 JE03-1760F strain has now been extended… CONTINUE READING


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