Culture, serotonin receptor polymorphism and locus of attention.


The present research examined the interaction between genes and culture as potential determinants of individuals' locus of attention. As the serotonin (5-HT) system has been associated with attentional focus and the ability to adapt to changes in reinforcement, we examined the serotonin 1A receptor polymorphism (5-HTR1A). Koreans and European Americans were genotyped and reported their chronic locus of attention. There was a significant interaction between 5-HTR1A genotype and culture in the locus of attention. Koreans reported attending to the field more than European Americans, and this cultural difference was moderated by 5-HTR1A. There was a linear pattern such that those homozygous for the G allele, which is associated with reduced ability to adapt to changes in reinforcement, more strongly endorsed the culturally reinforced mode of thinking than those homozygous for the C allele, with those heterozygous in the middle. Our findings suggest that the same genetic predisposition can result in divergent psychological outcomes, depending on an individual's cultural context.

DOI: 10.1093/scan/nsp040

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@article{Kim2010CultureSR, title={Culture, serotonin receptor polymorphism and locus of attention.}, author={Heejung S. Kim and David K. Sherman and Shelley E. Taylor and Joni Y. Sasaki and Thai Q Chu and Chorong Ryu and Eunkook M. Suh and Jun Xu}, journal={Social cognitive and affective neuroscience}, year={2010}, volume={5 2-3}, pages={212-8} }