Culture duration and conditions affect the oscillations of cytoplasmic calcium concentration induced by glucose in mouse pancreatic islets

@article{Gilon1994CultureDA,
  title={Culture duration and conditions affect the oscillations of cytoplasmic calcium concentration induced by glucose in mouse pancreatic islets},
  author={Patrick Gilon and Jean Christophe Jonas and Dr. J. C. Henquin},
  journal={Diabetologia},
  year={1994},
  volume={37},
  pages={1007-1014}
}
The pattern of the increase in cytoplasmic Cai 2+ that glucose produces in beta cells has been reported to be highly variable. Here, we evaluated the influence of the culture duration (1–4 days) and conditions (5–10 mmol/l glucose) on Cai 2+ in normal mouse islets stimulated by glucose. After 1 day of culture in 10 mmol/l glucose, a rise of the glucose concentration from 3 to 15 mmol/l induced a triphasic change of Cai 2+ in the islets. A small initial decrease was followed by a large peak… CONTINUE READING

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Cytoplasmic Ca 2 + oscillations in pancreatic / 3cells

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The biophysical events involved in the stimulation of insulin release by arginine

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