Culture conditions improving the production of jadomycin B

  title={Culture conditions improving the production of jadomycin B},
  author={David L Jakeman and Cathy L. Graham and Wendy Young and Leo C. Vining},
  journal={Journal of Industrial Microbiology and Biotechnology},
The jadomycins are a unique family of benzoxazolophenanthridine antibiotics produced by Streptomyces venezuelae ISP5230 following heat or ethanol shock or phage infection. We have modified the culture conditions by altering the carbon source, buffer, inoculum size, and timing of ethanol shock, thereby reducing growing times and improving jadomycin B production. Our optimized conditions use glucose as the carbon source, MOPS as buffer, low concentrations of phosphate, a defined inoculum… CONTINUE READING

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The dynamic structure of jadomycin B and the amino acid incorporation step of its biosynthesis.

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