Cultivation of visna virus in tissue culture

@article{Sigurdsson2005CultivationOV,
  title={Cultivation of visna virus in tissue culture},
  author={Bj{\"o}rn Sigurdsson and Halld{\'o}r Thormar and P{\'a}ll A. P{\'a}lsson},
  journal={Archiv f{\"u}r die gesamte Virusforschung},
  year={2005},
  volume={10},
  pages={368-381}
}
The virus of Visna, a slow, demyelinating leucoencephalitis of sheep, has been cultivated in tissue culture. The cells employed are derived from the chorioid plexus of sheep. The virus causes characteristic cytopathic changes in the culture, so that the method may be used to detect virus activity and measure the activity of virus containing material. Virus which had undergone 3, 11, and 12 passages in TC was injected intracerebrally into sheep and found to produce typical Visna lesions… CONTINUE READING