Cullin4A and cullin4B are interchangeable for HIV Vpr and Vpx action through the CRL4 ubiquitin ligase complex.

@article{Sharifi2014Cullin4AAC,
  title={Cullin4A and cullin4B are interchangeable for HIV Vpr and Vpx action through the CRL4 ubiquitin ligase complex.},
  author={Hamayun John Sharifi and Andrea K. M. Furuya and Robert M. Jellinger and Michael D. Nekorchuk and Carlos M. C. de Noronha},
  journal={Journal of virology},
  year={2014},
  volume={88 12},
  pages={6944-58}
}
UNLABELLED Human immunodeficiency virus (HIV) seizes control of cellular cullin-RING E3 ubiquitin ligases (CRLs) to promote viral replication. HIV-1 Vpr and HIV-2/simian immunodeficiency virus (SIV) Vpr and Vpx engage the cullin4 (CUL4)-containing ubiquitin ligase complex (CRL4) to cause polyubiquitination and proteasomal degradation of host proteins, including ones that block infection. HIV-1 Vpr engages CRL4 to trigger the degradation of uracil-N-glycosylase 2 (UNG2). Both HIV-1 Vpr and HIV-2… CONTINUE READING

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