Cullin-3 and its adaptor protein ANKFY1 determine the surface level of integrin β1 in endothelial cells

@inproceedings{Maekawa2017Cullin3AI,
  title={Cullin-3 and its adaptor protein ANKFY1 determine the surface level of integrin β1 in endothelial cells},
  author={Masashi Maekawa and Kazufumi Tanigawa and Tomohisa Sakaue and Hiromi Hiyoshi and Eiji Kubota and Takashi Joh and Yuji Watanabe and Tomohiko Taguchi and Shigeki Higashiyama},
  booktitle={Biology open},
  year={2017}
}
Angiogenesis, the formation of new blood vessels from the pre-existing vasculature, is related to numerous pathophysiological events. We previously reported that a RING ubiquitin ligase complex scaffold protein, cullin-3 (CUL3), and one of its adaptor proteins, BAZF, regulated angiogenesis in the mouse retina by suppressing Notch signaling. However, the degree of inhibition of angiogenesis was made greater by CUL3 depletion than by BAZF depletion, suggesting other roles of CUL3 in angiogenesis… CONTINUE READING
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