Cullin 3 Ubiquitin Ligases in Cancer Biology: Functions and Therapeutic Implications


Cullin-RING ubiquitin ligases are the largest E3 ligase family in eukaryotes and are multiprotein complexes. In these complexes, the Cullin protein serves as a scaffold to connect two functional modules of the ligases, the catalytic subunit and substrate-binding subunit. To date, eight members of the Cullin family proteins have been identified. In the Cul3… (More)
DOI: 10.3389/fonc.2016.00113