Cullin 3 Ubiquitin Ligases in Cancer Biology: Functions and Therapeutic Implications

@inproceedings{Chen2016Cullin3U,
  title={Cullin 3 Ubiquitin Ligases in Cancer Biology: Functions and Therapeutic Implications},
  author={Hsin-Yi Chen and R H Chen},
  booktitle={Front. Oncol.},
  year={2016}
}
Cullin-RING ubiquitin ligases are the largest E3 ligase family in eukaryotes and are multiprotein complexes. In these complexes, the Cullin protein serves as a scaffold to connect two functional modules of the ligases, the catalytic subunit and substrate-binding subunit. To date, eight members of the Cullin family proteins have been identified. In the Cul3 ubiquitin ligases, Bric-a-brac/Tramtrack/Broad complex (BTB) domain-containing proteins function as a bridge to connect Cul3 and substrates… CONTINUE READING
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