Cullin-1 regulates MG63 cell proliferation and metastasis and is a novel prognostic marker of osteosarcoma.

@article{Cheng2017Cullin1RM,
  title={Cullin-1 regulates MG63 cell proliferation and metastasis and is a novel prognostic marker of osteosarcoma.},
  author={Qinghua Cheng and Guoyong Yin},
  journal={The International journal of biological markers},
  year={2017},
  volume={32 2},
  pages={e202-e209}
}
BACKGROUND There is no reliable marker available for early detection, diagnostic confirmation or disease prognosis of osteosarcoma. Cullin-1 (CUL1) is a newly reported tumor-related gene, and we aimed to unravel its role in osteosarcoma. METHODS We used immunohistochemistry to analyze the correlation between CUL1 expression and clinicopathological variables and patient survival. To evaluate the function of CUL1, a group of 28 osteosarcoma patients were recruited for this study. The role of… CONTINUE READING