Cue-induced cocaine seeking and relapse are reduced by disruption of drug memory reconsolidation.

@article{Lee2006CueinducedCS,
  title={Cue-induced cocaine seeking and relapse are reduced by disruption of drug memory reconsolidation.},
  author={Jonathan L. C. Lee and Amy L Milton and Barry J. Everitt},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2006},
  volume={26 22},
  pages={5881-7}
}
Long-lasting vulnerability to drug cue-induced relapse to a drug-taking habit is a major challenge to the treatment of drug addiction. Here we show that blockade of drug memory reconsolidation, through infusion of Zif268 antisense oligodeoxynucleotides into the basolateral amygdala shortly before reexposure to a cocaine-associated stimulus but not simply to the training context, severely impaired subsequently cue-maintained cocaine seeking under a second-order schedule of reinforcement and… CONTINUE READING
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