Cucurbitacin induces autophagy through mitochondrial ROS production which counteracts to limit caspase-dependent apoptosis.

@article{Zhang2012CucurbitacinIA,
  title={Cucurbitacin induces autophagy through mitochondrial ROS production which counteracts to limit caspase-dependent apoptosis.},
  author={Tiejun Zhang and Yuwen Li and Kyeong Ah Park and Hee Sun Byun and Minho Won and Juhee Jeon and Yoonjung Lee and Jeong Ho Seok and Seung-Won Choi and Sang-Hee Lee and Jin Man Kim and Ji Hoon Lee and Chang Gue Son and Zee-won Lee and Han-ming Shen and Gang Min Hur},
  journal={Autophagy},
  year={2012},
  volume={8 4},
  pages={
          559-76
        }
}
Targeted disruption of STAT3 function has proven to be a useful cancer therapeutic approach by inducing apoptotic cell death. Cucurbitacin is currently under development as a small molecule of STAT3 inhibitor to trigger cell death in many cancers. Here, we systematically studied the molecular mechanisms underlying cucurbitacin-induced cell death, in particular the involvement of autophagy. Treatment with cucurbitacin resulted in non-apoptotic cell death in a caspase-independent manner. Notably… CONTINUE READING
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