Cucurbitacin E, a tetracyclic triterpenes compound from Chinese medicine, inhibits tumor angiogenesis through VEGFR2-mediated Jak2-STAT3 signaling pathway.

Abstract

Cucurbitacin E (CuE, α-elaterin), a tetracyclic triterpenes compound from folk traditional Chinese medicine plants, has been shown to inhibit cancer cell growth, inflammatory response and bilirubin-albumin binding. However, the effects of CuE on tumor angiogenesis and its potential molecular mechanism are still unknown. Here, we demonstrated that CuE… (More)
DOI: 10.1093/carcin/bgq167

Topics

Cite this paper

@article{Dong2010CucurbitacinEA, title={Cucurbitacin E, a tetracyclic triterpenes compound from Chinese medicine, inhibits tumor angiogenesis through VEGFR2-mediated Jak2-STAT3 signaling pathway.}, author={Yanmin Dong and Binbin Lu and Xiaoli Zhang and Jing Zhang and Li Lai and Dali Li and Yuanyuan Wu and Yajuan Song and Jian Luo and Xiufeng Pang and Zhengfang Yi and Mingyao Liu}, journal={Carcinogenesis}, year={2010}, volume={31 12}, pages={2097-104} }