Cubilin- and megalin-mediated uptake of albumin in cultured proximal tubule cells of opossum kidney.

@article{Zhai2000CubilinAM,
  title={Cubilin- and megalin-mediated uptake of albumin in cultured proximal tubule cells of opossum kidney.},
  author={X Y Zhai and Rikke Paludan Nielsen and Henrik Birn and Karina Drumm and Sigrid Mildenberger and Ruth Freudinger and S\oren K Moestrup and Pierre J. Verroust and Erik Ils\o Christensen and Michael Gekle},
  journal={Kidney international},
  year={2000},
  volume={58 4},
  pages={1523-33}
}
BACKGROUND Reabsorption of albumin from the glomerular filtrate occurs via receptor-mediated endocytosis in the proximal tubule. This process is initiated by binding of albumin in apical clathrin-coated pits, followed by endocytosis and degradation in lysosomes. Although binding sites have been characterized by kinetic studies, the receptors responsible for the binding of albumin have not been fully identified. Two giant glycoproteins, cubilin and megalin, constitute important endocytic… CONTINUE READING
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