CuCl-K2CO3-catalyzed highly selective borylcupration of internal alkynes--ligand effect.


An efficient and practical copper-catalyzed highly regio- and stereoselective borylcupration of internal alkynes with bis(pinacolato)diboron using a catalytic amount of K(2)CO(3) as base producing Z-alkenylboron compounds has been demonstrated by applying the ligand effect: commercially available electron-rich tris(p-methoxyphenyl) phosphine ensures a smooth and efficient reaction. Functionalized alkynes, such as propargylic alcohols and derivatives as well as N-propargyl tosylamide, may also be used with excellent selectivity.

DOI: 10.1039/c2ob26147b

Cite this paper

@article{Yuan2012CuClK2CO3catalyzedHS, title={CuCl-K2CO3-catalyzed highly selective borylcupration of internal alkynes--ligand effect.}, author={Weiming Yuan and Shengming Ma}, journal={Organic & biomolecular chemistry}, year={2012}, volume={10 36}, pages={7266-8} }