Cu-sensing transcription factor Mac1 coordinates with the Ctr transporter family to regulate Cu acquisition and virulence in Aspergillus fumigatus.

@article{Cai2017CusensingTF,
  title={Cu-sensing transcription factor Mac1 coordinates with the Ctr transporter family to regulate Cu acquisition and virulence in Aspergillus fumigatus.},
  author={Zhendong Cai and Wenlong Du and Qiuqiong Zeng and Nanbiao Long and Chuanchao Dai and Ling Lu},
  journal={Fungal genetics and biology : FG & B},
  year={2017},
  volume={107},
  pages={
          31-43
        }
}
Copper (Cu) is an essential trace element and is regarded as an important virulence factor in fungal pathogens. Previous studies suggest that a putative Cu-sensing transcription factor Mac1 and the Cu transporter Ctr family play important roles during fungal development and virulence. However, how Cu importers of the Ctr family are involved in the Cu acquisition and what is the functional relationship between them have not been fully investigated yet. Here, we demonstrate that the yeast Mac1… CONTINUE READING

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