Cu-DOTATATE PET / MRI for Detection of Activated Macrophages in Carotid Atherosclerotic Plaques Studies in Patients Undergoing Endarterectomy
@inproceedings{Pedersen2015CuDOTATATEP, title={Cu-DOTATATE PET / MRI for Detection of Activated Macrophages in Carotid Atherosclerotic Plaques Studies in Patients Undergoing Endarterectomy}, author={Sune Folke Pedersen and Benjamin Vikj and r Sandholt and Sune H{\o}gild Keller and Adam Espe Hansen and Andreas Clemmensen and Henrik Sillesen and Liselotte H{\o}jgaard and Rasmus Sejersten Ripa and Andreas Kj}, year={2015} }
Carotid atherosclerosis is a major risk factor of stroke and transient ischemic attack. Randomized trials have shown that carotid endarterectomy significantly reduces the risk of recurrent stroke in patients with recent symptoms of transient ischemic attack or stroke and at least 50% stenosis of the relevant carotid artery. However, not all patients will benefit from the surgery because some will have stable plaques that are not prone to cause new thromboembolic lesions. In addition, many…
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References
SHOWING 1-10 OF 44 REFERENCES
In vivo 18F-fluorodeoxyglucose positron emission tomography imaging provides a noninvasive measure of carotid plaque inflammation in patients.
- Medicine, BiologyJournal of the American College of Cardiology
- 2006
Imaging Atherosclerotic Plaque Inflammation With [18F]-Fluorodeoxyglucose Positron Emission Tomography
- Medicine, BiologyCirculation
- 2002
It is demonstrated that atherosclerotic plaque inflammation can be imaged with 18 FDG-PET, and that symptomatic, unstable plaques accumulate more 18FDG than asymptomatic lesions.
Gene expression and 18FDG uptake in atherosclerotic carotid plaques
- BiologyNuclear medicine communications
- 2010
It is suggested that FDG uptake is a composite indicator of macrophage load, overall inflammatory activity and collagenolytic plaque destabilization and could prove to be an important predictor of cerebrovascular events in patients with carotid plaques.
When to image carotid plaque inflammation with FDG PET/CT
- Medicine, BiologyNuclear medicine communications
- 2010
Identification of carotid plaque inflammation with PET can be performed 1 h after FDG injection using SUVmax for plaque FDG uptake quantification, and absolute values changed over time.
Molecular pathology in vulnerable carotid plaques: correlation with [18]-fluorodeoxyglucose positron emission tomography (FDG-PET).
- Biology, MedicineEuropean journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery
- 2009
In Vivo Imaging of Macrophage Activity in the Coronary Arteries Using 68Ga-DOTATATE PET/CT: Correlation with Coronary Calcium Burden and Risk Factors
- MedicineJournal of Nuclear Medicine
- 2010
In a series of oncologic patients, those with prior cardiovascular events and calcified atherosclerotic plaques showed significantly increased 68Ga-DOTATATE uptake in the LAD, suggesting a potential role of this tracer for plaque imaging in the coronary arteries.
Microvessel Density But Not Neoangiogenesis Is Associated with 18F-FDG Uptake in Human Atherosclerotic Carotid Plaques
- BiologyMolecular Imaging and Biology
- 2011
The absence of correlation between markers of neoangiogenesis and 18FDG uptake suggests a temporal separation between the process of neoangelicogenesis and inflammatory activity.
68Ga-DOTATATE PET/CT for the detection of inflammation of large arteries: correlation with18F-FDG, calcium burden and risk factors
- Biology, MedicineEJNMMI Research
- 2012
A stronger association of increased 68Ga-DOTATATE uptake with known risk factors of cardiovascular disease as compared to 18F-FDG is found, suggesting a potential role for plaque imaging in large arteries.
Distribution of Inflammation Within Carotid Atherosclerotic Plaques With High-Risk Morphological Features: A Comparison Between Positron Emission Tomography Activity, Plaque Morphology, and Histopathology
- MedicineCirculation. Cardiovascular imaging
- 2012
Inflammation, as assessed by both FDG uptake and histology, is increased in plaques containing HRM and increases with increasing number of HRM, supporting the concept that inflammation accumulates relative to the burden of morphological abnormalities.
Feasibility of simultaneous PET/MR of the carotid artery: first clinical experience and comparison to PET/CT.
- MedicineAmerican journal of nuclear medicine and molecular imaging
- 2013
The study shows for the first time that simultaneous PET/MR of the carotid arteries is feasible in patients with increased risk of atherosclerosis and quantification of (18)F-FDG uptake correlated well despite difference in method of PET attenuation correction, reconstruction algorithm, and detector technology.