Cu/Zn superoxide dismutase-like immunoreactivity is present in Lewy bodies from Parkinson disease: a light and electron microscopic immunocytochemical study

@article{Nishiyama1995CuZnSD,
  title={Cu/Zn superoxide dismutase-like immunoreactivity is present in Lewy bodies from Parkinson disease: a light and electron microscopic immunocytochemical study},
  author={Kazutoshi Nishiyama and Shigeo Murayama and Jun Shimizu and Yuriko Ohya and Shin Hye Kwak and Kohtaro Asayama and Itaru Kanazawa},
  journal={Acta Neuropathologica},
  year={1995},
  volume={89},
  pages={471-474}
}
Copper-zinc superoxide dismutase (SOD1)-like immunoreactivity has been demonstrated in Lewy body-like inclusions (LIs) in brain tissues from patients with familial and sporadic amyotrophic lateral sclerosis. Using immunocytochemistry, we studied Lewy bodies (LBs), the original inclusions from which the term LI was derived, in five patients with Parkinson disease (PD). Surprisingly, many LBs were immunostained by an antibody against SOD1. There were two types of staining pattern: a diffuse… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 12 REFERENCES

Models of motor neuron disease - etiologies, mechanisms and therapies (abstract)

DL Price
  • Brain Pathol
  • 1994
VIEW 1 EXCERPT

Immunohistochemical localization of superoxide dismutases in the central nervous system with various types of disorders

N Shibata, M Kobayashi
  • Neuropathology (Kyoto)
  • 1991
VIEW 1 EXCERPT

Immunocytochemical and ultrastructural study of Lewy body-like hyaline inclusions in familial amyotrophic lateral sclerosis

S. Murayama, Y. Ookawa, +4 authors M. Tomonaga
  • Acta Neuropathologica
  • 1989
VIEW 1 EXCERPT