Cu/Zn superoxide dismutase gene mutations in amyotrophic lateral sclerosis: correlation between genotype and clinical features.

@article{Radunovi1996CuZnSD,
  title={Cu/Zn superoxide dismutase gene mutations in amyotrophic lateral sclerosis: correlation between genotype and clinical features.},
  author={Aleksandar Radunovi{\'c} and Peter Nigel Leigh},
  journal={Journal of neurology, neurosurgery, and psychiatry},
  year={1996},
  volume={61 6},
  pages={565-72}
}
Received 21 May 1996 and in revised form 2 September 1996 Accepted 9 September 1996 Background Amyotrophic lateral sclerosis (ALS) is a fatal disease in which degeneration of upper and lower motor neurons leads to progressive weakness of bulbar, limb, thoracic, and abdominal muscles with relative sparing of oculomotor muscles and sphincter function. Although the clinical manifestations and pathological changes have been known since the time of Charcot and Joffroy,' the cellular and molecular… CONTINUE READING
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A novel missense point mutation S 134 N of the Cu / Zn superoxide dismutase gene in a patient with fami - lal motor neuron disease

  • M Watanabe, M Aoki, K Abe, M Shoji, T lizuka, Y Ikeda
  • Hum Mutat
  • 1996

D 90 A heterozygosity in the SOD 1 gene is associated with familial and apparently sporadic amyotrophic lateral sclerosis

  • W Robberecht, T Aguirre, L VanDenBosch, P Tilkin, JJ Cassiman, G Matthijs
  • Neurology
  • 1996

Molecular pathology of familial amyotrophic lateral sclerosis ALS with a mutation of SOD 1 [ abstract ]

  • CE Shaw, Anderson VER, S Al-Sarraj, PL Lantos, PN Leigh
  • Neuropathol Appl Neurobiol
  • 1996

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