Cu,Zn-superoxide dismutase is necessary for proper function of VDAC in Saccharomyces cerevisiae cells.

@article{Karachitos2009CuZnsuperoxideDI,
  title={Cu,Zn-superoxide dismutase is necessary for proper function of VDAC in Saccharomyces cerevisiae cells.},
  author={Andonis Karachitos and Hanna Galganska and Malgorzata Wojtkowska and Malgorzata Budzińska and Olgierd Stobienia and Grzegorz Bartosz and Hanna Kmita},
  journal={FEBS letters},
  year={2009},
  volume={583 2},
  pages={
          449-55
        }
}
Available data suggest that a copper-and zinc-containing dismutase (CuZnSOD) plays a significant role in protecting eukaryotic cells against oxidative modifications which may contribute to cell aging. Here we demonstrated that depletion of CuZnSOD in Saccharomyces cerevisiae cells (Deltasod1 cells) affected distinctly channel activity of VDAC (voltage dependent anion selective channel) and resulted in a moderate reduction in VDAC levels as well as in levels of protein crucial for VDAC import… CONTINUE READING
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