Ctp1 is a cell-cycle-regulated protein that functions with Mre11 complex to control double-strand break repair by homologous recombination.

@article{Limbo2007Ctp1IA,
  title={Ctp1 is a cell-cycle-regulated protein that functions with Mre11 complex to control double-strand break repair by homologous recombination.},
  author={Oliver Limbo and Charly Chahwan and Yoshiki Yamada and Robertus Antonius Maria de Bruin and Curt Wittenberg and Paul Russell},
  journal={Molecular cell},
  year={2007},
  volume={28 1},
  pages={134-46}
}
The Mre11-Rad50-Nbs1 (MRN) complex is a primary sensor of DNA double-strand breaks (DSBs). Upon recruitment to DSBs, it plays a critical role in catalyzing 5' --> 3' single-strand resection that is required for repair by homologous recombination (HR). Unknown mechanisms repress HR in G1 phase of the cell cycle during which nonhomologous end-joining (NHEJ) is the favored mode of DSB repair. Here we describe fission yeast Ctp1, so-named because it shares conserved domains with the mammalian tumor… CONTINUE READING
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