Ctp1 and the MRN-Complex Are Required for Endonucleolytic Rec12 Removal with Release of a Single Class of Oligonucleotides in Fission Yeast

@inproceedings{Rothenberg2009Ctp1AT,
  title={Ctp1 and the MRN-Complex Are Required for Endonucleolytic Rec12 Removal with Release of a Single Class of Oligonucleotides in Fission Yeast},
  author={Maja Rothenberg and Juerg Kohli and Katja Maria Ludin},
  booktitle={PLoS genetics},
  year={2009}
}
DNA double-strand breaks (DSBs) are formed during meiosis by the action of the topoisomerase-like Spo11/Rec12 protein, which remains covalently bound to the 5' ends of the broken DNA. Spo11/Rec12 removal is required for resection and initiation of strand invasion for DSB repair. It was previously shown that budding yeast Spo11, the homolog of fission yeast Rec12, is removed from DNA by endonucleolytic cleavage. The release of two Spo11 bound oligonucleotide classes, heterogeneous in length, led… CONTINUE READING

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Double functions for the Mre11 complex during DNA double-strand break repair and replication.

The international journal of biochemistry & cell biology • 2009
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