Cti6, a PHD domain protein, bridges the Cyc8-Tup1 corepressor and the SAGA coactivator to overcome repression at GAL1.

@article{PapamichosChronakis2002Cti6AP,
  title={Cti6, a PHD domain protein, bridges the Cyc8-Tup1 corepressor and the SAGA coactivator to overcome repression at GAL1.},
  author={Manolis Papamichos-Chronakis and Theodoros Petrakis and Eleni Ktistaki and Irini Topalidou and Dimitris Tzamarias},
  journal={Molecular cell},
  year={2002},
  volume={9 6},
  pages={1297-305}
}
The yeast Cyc8 and Tup1 proteins form a corepressor complex that, when tethered to DNA, turns off transcription. Release of the Cyc8-Tup1 corepressor from a promoter has been considered as a prerequisite for subsequent transcriptional activation. Contrasting this, we demonstrate that Cyc8-Tup1 is continuously associated with target promoters under both repressive and inducing conditions. At the GAL1 promoter, Cyc8-Tup1 facilitates recruitment of SAGA (Spt-Ada-Gcn5-acetyltranferase) via Cti6, a… CONTINUE READING

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