Ctf4 Is a Hub in the Eukaryotic Replisome that Links Multiple CIP-Box Proteins to the CMG Helicase

@inproceedings{Villa2016Ctf4IA,
  title={Ctf4 Is a Hub in the Eukaryotic Replisome that Links Multiple CIP-Box Proteins to the CMG Helicase},
  author={Fabrizio Villa and A. Cobbold Simon and Maria Angeles Ortiz Bazan and Mairi Louise Kilkenny and David C Wirthensohn and Mel Wightman and Dijana Matak-Vinkov{\'i}c and Luca Pellegrini and Karim Labib},
  booktitle={Molecular cell},
  year={2016}
}
Replisome assembly at eukaryotic replication forks connects the DNA helicase to DNA polymerases and many other factors. The helicase binds the leading-strand polymerase directly, but is connected to the Pol α lagging-strand polymerase by the trimeric adaptor Ctf4. Here, we identify new Ctf4 partners in addition to Pol α and helicase, all of which contain a "Ctf4-interacting-peptide" or CIP-box. Crystallographic analysis classifies CIP-boxes into two related groups that target different sites on… CONTINUE READING
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