CtIP maintains stability at common fragile sites and inverted repeats by end resection-independent endonuclease activity.

Abstract

Chromosomal rearrangements often occur at genomic loci with DNA secondary structures, such as common fragile sites (CFSs) and palindromic repeats. We developed assays in mammalian cells that revealed CFS-derived AT-rich sequences and inverted Alu repeats (Alu-IRs) are mitotic recombination hotspots, requiring the repair functions of carboxy-terminal binding… (More)
DOI: 10.1016/j.molcel.2014.04.012

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