CtIP is required for DNA damage-dependent induction of P21

  title={CtIP is required for DNA damage-dependent induction of P21},
  author={Bo Liu and Rixin Cong and Bin Peng and Bingtao Zhu and Gelin Dou and Haiyan Ai and Xiaodong Zhang and Zhenghe Wang and Xingzhi Xu},
  booktitle={Cell cycle},
DNA endonuclease CtIP is involved in both DNA double-strand break (DSB) repair and transcriptional repression/activation. The cyclin-dependent kinase inhibitor P21, which is induced at transcription level in response to a variety of stresses, controls G₁/S transition. In this report, we found that CtIP bound to the P21 promoter, and this binding was enhanced in response to DNA damage. Concomitantly, ectopic expression of CtIP increased P21 promoter activity, and this increment was enhanced upon… CONTINUE READING

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