CsrA and Cra influence Shigella flexneri pathogenesis.

@article{Gore2010CsrAAC,
  title={CsrA and Cra influence Shigella flexneri pathogenesis.},
  author={Aja Lynne Gore and Shelley M Payne},
  journal={Infection and immunity},
  year={2010},
  volume={78 11},
  pages={
          4674-82
        }
}
Shigella flexneri is a facultative intracellular pathogen that invades and disrupts the colonic epithelium. In order to thrive in the host, S. flexneri must adapt to environmental conditions in the gut and within the eukaryotic cytosol, including variability in the available carbon sources and other nutrients. We examined the roles of the carbon consumption regulators CsrA and Cra in a cell culture model of S. flexneri virulence. CsrA is an activator of glycolysis and a repressor of… CONTINUE READING
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