CspA-mediated binding of human factor H inhibits complement deposition and confers serum resistance in Borrelia burgdorferi.

@article{Kenedy2009CspAmediatedBO,
  title={CspA-mediated binding of human factor H inhibits complement deposition and confers serum resistance in Borrelia burgdorferi.},
  author={Melisha R. Kenedy and Santosh R Vuppala and Corinna Siegel and Peter Kraiczy and Darrin R. Akins},
  journal={Infection and immunity},
  year={2009},
  volume={77 7},
  pages={
          2773-82
        }
}
Borrelia burgdorferi has developed efficient mechanisms for evading the innate immune response during mammalian infection and has been shown to be resistant to the complement-mediated bactericidal activity of human serum. It is well recognized that B. burgdorferi expresses multiple lipoproteins on its surface that bind the human complement inhibitors factor H and factor H-like protein 1 (FH/FHL-1). The binding of FH/FHL-1 on the surface of B. burgdorferi is thought to enhance its ability to… CONTINUE READING

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