CspA, the major cold-shock protein of Escherichia coli, is an RNA chaperone.

@article{Jiang1997CspATM,
  title={CspA, the major cold-shock protein of Escherichia coli, is an RNA chaperone.},
  author={Wei Jiang and Y Hou and M. Inouye},
  journal={The Journal of biological chemistry},
  year={1997},
  volume={272 1},
  pages={196-202}
}
CspA, the major cold-shock protein of Escherichia coli, is dramatically induced during the cold-shock response. The amino acid sequence of CspA shows 43% identity to the "cold-shock domain" of the eukaryotic Y-box protein family, which interacts with RNA and DNA to regulate their functions. Here, we demonstrate that CspA binds to RNA as a chaperone. First, CspA cooperatively binds to heat-denatured single-stranded RNA if it is larger than 74 bases, causing a supershift in gel electrophoresis. A… CONTINUE READING
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CspA Is an RNA Chaperone 202 by gest on Jne 23

  • M. Ranjan, S. R. Tafuri, A. P. Wolffe
  • Proc. Natl. Acad. Sci. U. S. A
  • 1984

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