Csk, a critical link of g protein signals to actin cytoskeletal reorganization.

@article{Lowry2002CskAC,
  title={Csk, a critical link of g protein signals to actin cytoskeletal reorganization.},
  author={William E Lowry and Jianyun Huang and Y Ma and Shariq Ali and Dongxia Wang and Daniel M. Williams and Masato Okada and Philip A Cole and X. X. Huang},
  journal={Developmental cell},
  year={2002},
  volume={2 6},
  pages={733-44}
}
Heterotrimeric G proteins can signal to reorganize the actin cytoskeleton, but the mechanism is unclear. Here we report that, in tyrosine kinase Csk-deficient mouse embryonic fibroblast cells, G protein (Gbetagamma, Galpha(12), Galpha(13), and Galpha(q))-induced, and G protein-coupled receptor-induced, actin stress fiber formation was completely blocked. Reintroduction of Csk into Csk-deficent cells restored the G protein-induced actin stress fiber formation. Chemical rescue experiments with… CONTINUE READING