Cse1p-binding dynamics reveal a binding pattern for FG-repeat nucleoporins on transport receptors.

@article{Isgro2007Cse1pbindingDR,
  title={Cse1p-binding dynamics reveal a binding pattern for FG-repeat nucleoporins on transport receptors.},
  author={Timothy A. Isgro and Klaus Schulten},
  journal={Structure},
  year={2007},
  volume={15 8},
  pages={977-91}
}
Nuclear pore proteins with phenylalanine-glycine repeats are vital to the functional transport of molecules across the nuclear pore complex. The current study investigates the binding of these FG-nucleoporins to the Cse1p:Kap60p:RanGTP nuclear export complex. Fourteen binding spots for FG-nucleoporin peptides are revealed on the surface of Cse1p, and 5 are revealed on the Kap60p surface. Taken together, and along with binding data for two other transport receptors, the data suggest that the… CONTINUE READING

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