Crystallographic studies on acyl ureas, a new class of glycogen phosphorylase inhibitors, as potential antidiabetic drugs.

@article{Oikonomakos2005CrystallographicSO,
  title={Crystallographic studies on acyl ureas, a new class of glycogen phosphorylase inhibitors, as potential antidiabetic drugs.},
  author={Nikos G. Oikonomakos and Magda N Kosmopoulou and Evangelia D Chrysina and Demetres D Leonidas and Ioannis Kostas and K. Ulrich Wendt and Thomas Klabunde and Elisabeth Defossa},
  journal={Protein science : a publication of the Protein Society},
  year={2005},
  volume={14 7},
  pages={1760-71}
}
Acyl ureas were discovered as a novel class of inhibitors for glycogen phosphorylase, a molecular target to control hyperglycemia in type 2 diabetics. This series is exemplified by 6-{2,6-Dichloro- 4-[3-(2-chloro-benzoyl)-ureido]-phenoxy}-hexanoic acid, which inhibits human liver glycogen phosphorylase a with an IC(50) of 2.0 microM. Here we analyze four crystal structures of acyl urea derivatives in complex with rabbit muscle glycogen phosphorylase b to elucidate the mechanism of inhibition of… CONTINUE READING

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This series is exemplified by 6-{2,6-Dichloro- 4-[3-(2-chloro - benzoyl)-ureido]-phenoxy}-hexanoic acid , which inhibits human liver glycogen phosphorylase a with an IC(50 ) of 2.0 microM. Here we analyze four crystal structures of acyl urea derivatives in complex with rabbit muscle glycogen phosphorylase b to elucidate the mechanism of inhibition of these inhibitors .
This series is exemplified by 6-{2,6-Dichloro- 4-[3-(2-chloro - benzoyl)-ureido]-phenoxy}-hexanoic acid , which inhibits human liver glycogen phosphorylase a with an IC(50 ) of 2.0 microM. Here we analyze four crystal structures of acyl urea derivatives in complex with rabbit muscle glycogen phosphorylase b to elucidate the mechanism of inhibition of these inhibitors .
This series is exemplified by 6-{2,6-Dichloro- 4-[3-(2-chloro - benzoyl)-ureido]-phenoxy}-hexanoic acid , which inhibits human liver glycogen phosphorylase a with an IC(50 ) of 2.0 microM. Here we analyze four crystal structures of acyl urea derivatives in complex with rabbit muscle glycogen phosphorylase b to elucidate the mechanism of inhibition of these inhibitors .
This series is exemplified by 6-{2,6-Dichloro- 4-[3-(2-chloro - benzoyl)-ureido]-phenoxy}-hexanoic acid , which inhibits human liver glycogen phosphorylase a with an IC(50 ) of 2.0 microM. Here we analyze four crystal structures of acyl urea derivatives in complex with rabbit muscle glycogen phosphorylase b to elucidate the mechanism of inhibition of these inhibitors .
This series is exemplified by 6-{2,6-Dichloro- 4-[3-(2-chloro - benzoyl)-ureido]-phenoxy}-hexanoic acid , which inhibits human liver glycogen phosphorylase a with an IC(50 ) of 2.0 microM. Here we analyze four crystal structures of acyl urea derivatives in complex with rabbit muscle glycogen phosphorylase b to elucidate the mechanism of inhibition of these inhibitors .
This series is exemplified by 6-{2,6-Dichloro- 4-[3-(2-chloro - benzoyl)-ureido]-phenoxy}-hexanoic acid , which inhibits human liver glycogen phosphorylase a with an IC(50 ) of 2.0 microM. Here we analyze four crystal structures of acyl urea derivatives in complex with rabbit muscle glycogen phosphorylase b to elucidate the mechanism of inhibition of these inhibitors .
This series is exemplified by 6-{2,6-Dichloro- 4-[3-(2-chloro - benzoyl)-ureido]-phenoxy}-hexanoic acid , which inhibits human liver glycogen phosphorylase a with an IC(50 ) of 2.0 microM. Here we analyze four crystal structures of acyl urea derivatives in complex with rabbit muscle glycogen phosphorylase b to elucidate the mechanism of inhibition of these inhibitors .
This series is exemplified by 6-{2,6-Dichloro- 4-[3-(2-chloro - benzoyl)-ureido]-phenoxy}-hexanoic acid , which inhibits human liver glycogen phosphorylase a with an IC(50 ) of 2.0 microM. Here we analyze four crystal structures of acyl urea derivatives in complex with rabbit muscle glycogen phosphorylase b to elucidate the mechanism of inhibition of these inhibitors .
This series is exemplified by 6-{2,6-Dichloro- 4-[3-(2-chloro - benzoyl)-ureido]-phenoxy}-hexanoic acid , which inhibits human liver glycogen phosphorylase a with an IC(50 ) of 2.0 microM. Here we analyze four crystal structures of acyl urea derivatives in complex with rabbit muscle glycogen phosphorylase b to elucidate the mechanism of inhibition of these inhibitors .
This series is exemplified by 6-{2,6-Dichloro- 4-[3-(2-chloro - benzoyl)-ureido]-phenoxy}-hexanoic acid , which inhibits human liver glycogen phosphorylase a with an IC(50 ) of 2.0 microM. Here we analyze four crystal structures of acyl urea derivatives in complex with rabbit muscle glycogen phosphorylase b to elucidate the mechanism of inhibition of these inhibitors .
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